| Download | - View accepted manuscript: Competitive interference between influenza viral strains (PDF, 806 KiB)
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| Author | Search for: Moghadas, Seyed M.1; Search for: Bowman, Christopher S.1; Search for: Arino, Julien |
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| Affiliation | - National Research Council of Canada. NRC Institute for Biodiagnostics
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| Format | Text, Article |
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| Subject | influenza; viral strains; cross-immunity; epidemic models |
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| Abstract | We propose a modelling framework for investigating the dynamics of competition between immunologically-related influenza viral strains in the absence of pre-existing immunity. Assuming that the host immune system will mount partial protection (cross-immunity) against one strain by virtue of having interacted with the other through exposure, we discuss the conditions for the occurrence of two distinct waves of infection during a single epidemic episode. Numerical simulations are presented to illustrate the possibility of infection waves with respect to the protection level induced by the first strain, and the time-lag for evolving the second strain. We propose directions for future work that involves extension of the model to include vaccination. |
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| Publication date | 2009-07-01 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 19726585 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 936b9860-8285-4df3-ae4a-8a4558fc244b |
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| Record created | 2012-03-28 |
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| Record modified | 2020-04-16 |
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