Dementia with Lewy bodies post-mortem brains reveal differentially methylated CpG sites with biomarker potential

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DOI

Resolve DOI: https://doi.org/10.1038/s42003-022-03965-x

Author

Search for: Shao, Xiaojian ORCID identifier: https://orcid.org/0000-0002-3044-621X; Search for: Vishweswaraiah, Sangeetha ORCID identifier: https://orcid.org/0000-0001-5681-5143; Search for: Čuperlović-Culf, Miroslava¹; Search for: Yilmaz, Ali; Search for: Greenwood, Celia M. T.ORCID identifier: https://orcid.org/0000-0002-2427-5696; Search for: Surendra, Anuradha¹; Search for: McGuinness, Bernadette; Search for: Passmore, Peter; Search for: Kehoe, Patrick G.ORCID identifier: https://orcid.org/0000-0002-7542-1139; Search for: Maddens, Michael E.; Search for: Bennett, Steffany A. L.; Search for: Green, Brian D.; Search for: Radhakrishna, Uppala ORCID identifier: https://orcid.org/0000-0002-6617-5634; Search for: Graham, Stewart F.ORCID identifier: https://orcid.org/0000-0003-1001-0002

Affiliation

National Research Council of Canada. Digital Technologies

Format

Text, Article

Subject

dementia; epigenetics in the nervous system

Abstract

Dementia with Lewy bodies (DLB) is a common form of dementia with known genetic and environmental interactions. However, the underlying epigenetic mechanisms which reflect these gene-environment interactions are poorly studied. Herein, we measure genome-wide DNA methylation profiles of post-mortem brain tissue (Broadmann area 7) from 15 pathologically confirmed DLB brains and compare them with 16 cognitively normal controls using Illumina MethylationEPIC arrays. We identify 17 significantly differentially methylated CpGs (DMCs) and 17 differentially methylated regions (DMRs) between the groups. The DMCs are mainly located at the CpG islands, promoter and first exon regions. Genes associated with the DMCs are linked to “Parkinson’s disease” and “metabolic pathway”, as well as the diseases of “severe intellectual disability” and “mood disorders”. Overall, our study highlights previously unreported DMCs offering insights into DLB pathogenesis with the possibility that some of these could be used as biomarkers of DLB in the future.

Publication date

2022-11-22

Publisher

Springer Nature

Licence

Creative Commons Attribution 4.0 International (CC BY 4.0)
https://creativecommons.org/licenses/by/4.0/

Language

English

Peer reviewed

Yes

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Record identifier

9268ad9e-e880-4c10-9a8c-26e69b3e8914

Record created

2023-01-20

Record modified

2023-01-20

Date modified:: 2025-11-16