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Association of Gap-43 (neuromodulin) with microtubule-associated protein MAP-2 in neuronal cells

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1016/j.bbrc.2008.04.119
AuthorSearch for: 1; Search for: 1; Search for: 1; Search for: 1; Search for: 1; Search for: 1
Affiliation
  1. National Research Council Canada. NRC Institute for Biological Sciences
FormatText, Article
SubjectGap-43; MAP-2; protein–protein interaction
Abstract
Gap-43 (B-50, neuromodulin) is a presynaptic protein implicated in axonal growth, neuronal differentiation, plasticity, and regeneration. Its activities are regulated by its dynamic interactions with various neuronal proteins, including actin and brain spectrin. Recently we have shown that Gap-43 co-localizes with an axonal protein DPYSL-3 in primary cortical neurons. In the present study we provide evidence that Gap-43 co-localizes and potentially interacts with microtubule-associated protein MAP-2 in adult and fetal rat brain, as well as in primary neuronal cultures. Our studies suggest that this interaction may be developmentally regulated.
Publication date
PublisherElsevier
In
  • Biochemical and Biophysical Research Communications 371, no. 4: 679–683.
LanguageEnglish
Peer reviewedYes
NRC numberCHAKRAVARTHY2008
NPARC number9358348
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Record identifier91814ebb-d7ee-44e3-87c6-5072fb2a4bca
Record created2009-07-10
Record modified2020-04-15
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