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Parathyroid hormone fragment [3-34] stimulates protein kinase C (PKC) activity in rat osteosarcoma and murine T-lymphoma cells

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1016/0006-291X(90)90798-R
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FormatText, Article
Abstract
The parathyroid hormone (PTH) fragment [1–34] strongly stimulated both adenylate cyclase and membrane-associated PKC activities in rat 17/2 osteosarcoma cells. By contrast, the PTH [3–34] fragment, which was unable to stimulate adenylate cyclase, remained a potent stimulator of membrane-associated PKC activity in these cells. Both PTH fragments also strongly stimulated membrane-PKC activity in S49T-lymphoma cells possessing a defective adenylate cyclase system. This ability of PTH [3–34] to stimulate membrane-associated PKC activity could explain the residual bioactivity of this fragment.
Publication date
PublisherElsevier
In
  • Biochemical and Biophysical Research Communications 171, no. 3: 1105–1110.
LanguageEnglish
Peer reviewedYes
NRC numberCHAKRAVARTHY1990
NPARC number9368381
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Record identifier90b5def2-0b0e-44b2-9d8f-9e8c62f2b8d7
Record created2009-07-10
Record modified2020-03-17
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