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A short route to L-iduronic acid building blocks for the syntheses of heparin-like disaccharides

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1016/j.tetlet.2003.08.092
AuthorSearch for: 1; Search for: 1; Search for: 1; Search for: 1; Search for: 1
Affiliation
  1. National Research Council of Canada. NRC Institute for Biological Sciences
FormatText, Article
Subjectglycosylations; carbohydrates; heparin; disaccharides
Abstract
The effective preparation of differentially protected l-iduronic acid derivatives, as building blocks for the synthesis of heparin-like oligosaccharides, is described in less than nine steps starting from readily available 1,2-O-isopropylidene-6,3-d-glucuronolactone. The pivaloyl group was used as a permanent protecting group of hydroxyl groups. Two heparin-like disaccharides with different sulfation pattern have been prepared by using these l-iduronic acid building blocks.
Publication date
In
  • Tetrahedron Letters 44, no. 42 (2003): 7767–7770.
LanguageEnglish
NRC numberKE2003
NPARC number9364752
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Record identifier8fc6cd5d-4dff-4d30-9fdb-3ff68534543e
Record created2009-07-10
Record modified2020-04-02
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