Structure-function analysis of cysteine-engineered entomopathogenic toxins

DOI	Resolve DOI: https://doi.org/10.1385/1-59259-052-7:101
Author	Search for: Schwartz, Jean-Louis¹ ; Search for: Masson, Luke¹
Name affiliation	National Research Council Canada. NRC Biotechnology Research Institute
Format	Text
Type	Book chapter
Series title	Methods in Molecular Biology; Volume 145
ISBN	978-0-89603-604-8 978-1-59259-052-0
Pages	101–113; # of pages: 13
Abstract	The availability of bacterial toxin genes and, in many cases, their atomic structures permits, through properly designed structure-function studies, the precise mapping of the molecular determinants of their activity. The results of such studies are of particular importance for the elucidation of the mode of action of the toxins and the design of genetically engineered molecules displaying novel activity. For example, a large effort is currently underway to design, through mutagenesis and chimeric constructs, the next generation of Bacillus thuringiensis toxin-based pesticides with different specificities, improved toxicity, and the potential to delay pest resistance.
Publication date	2000
Language	English
NRC number	BCENV05
NPARC number	3539172
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Record identifier	8d69f947-f229-45a2-8e63-215d33f2eb2d
Record created	2009-03-01
Record modified	2019-01-31