Light-responsive polymer brushes: active topographic cues for cell culture applications

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1039/C7PY00462A
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FormatText, Article
Journal titlePolymer Chemistry
ISSN1759-9954
1759-9962
Volume8
Issue21
Pages3271–3278
Abstract
In the call for novel stimuli-responsive biomaterials, azobenzene-containing polymer brushes entail a remarkable potential. In fact, their ability to be patterned at the micro- and nanoscale using interference lithography (IL) might be exploited for the realisation of cell-instructive materials (CIMs). In this work, Disperse Red 1 (DR1)-based photoresponsive polymer brushes were synthesised using a controlled radical polymerisation technique. A sinusoidal pattern was inscribed on the azopolymer brush samples using Lloyd's IL configuration. Interestingly, we found that seeded human umbilical vein endothelial cells (HUVECs) oriented in the pattern direction. Furthermore, using a non-cytotoxic ultrasonication treatment, pattern erasure was achieved. Hence, we envisage the possibility of using these surfaces as reconfigurable cell-instructive biomaterials for tissue engineering applications.
Publication date
PublisherRoyal Society of Chemistry
LanguageEnglish
Peer reviewedYes
NPARC number23003182
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Record created2018-05-04
Record modified2020-03-16
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