| Download | - View final version: Quantitative high-throughput analysis of domoic acid in mussel tissue homogenates using laser ablation electrospray ionization – MS/MS (PDF, 532 KiB)
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| Author | Search for: Beach, Daniel1; Search for: Walsh, Callee M.; Search for: McCarron, Pearse1 |
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| Affiliation | - National Research Council of Canada. Measurement Science and Standards
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| Format | Text, Address |
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| Conference | 30th Montreaux LC/MS Symposium, 3–7 November 2014, Charleston, USA |
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| Abstract | We investigated the use of Laser Ablation Electrospray Ionization (LAESI) with MS/MS detection for Domoic Acid (DA) analysis directly from mussel tissue homogenates without sample extraction, cleanup or chromatographic separation. DA could be selectively detected directly from mussel tissue homogenates using LAESI-MS/MS in selected reaction monitoring scan mode. A matrix matched calibration curve was used to quantify mussel tissue reference materials and results were in good agreement with two established methods, LC-UV and LC-MS/MS, within the linear range. Most notable is the decrease in run time from about 20 minutes for a typical chromatographic method to about 10 seconds per sample for LAESI-MS/MS. |
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| Publication date | 2014-11 |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 23002022 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 8a18e683-ac07-4502-a1f5-e6d97c095119 |
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| Record created | 2017-07-21 |
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| Record modified | 2020-05-30 |
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