Design and synthesis of analogs of vitamin E : Antiproliferative activity against human breast adenocarcinoma cells

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DOI	Resolve DOI: https://doi.org/10.1016/S0960-894X(98)00438-7
Author	Search for: Arya, P.¹; Search for: Alibhai, N.¹; Search for: Qin, H.¹; Search for: Burton, G. W.¹; Search for: Batist, G.; Search for: You, S. X.-L.; Search for: Alaoui-Jamali, M. A.
Affiliation	National Research Council Canada. NRC Steacie Institute for Molecular Sciences
Format	Text, Article
Abstract	Analogs of [alpha]-tocopherol (vitamin E; compounds 3-9) have been synthesized and tested for their antiproliferative activity using the human breast cancer cell line, MCF7. Compounds 6-9 were synthesized from a common synthon, rac-Trolox (14) and are soluble/miscible at physiological pH. Compounds 4, 8, and 9 were found to have antiproliferative activity at micromolar concentrations.
Publication date	1998-09-22
In	Bioorganic & Medicinal Chemistry Letters 8, no. 18 (22 September 1998): 2433–2438.
Language	English
NPARC number	12327322
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Record identifier	8843141c-6dc4-4211-bec3-3cccb85fbbb9
Record created	2009-09-10
Record modified	2020-03-20