| DOI | Resolve DOI: https://doi.org/10.1016/j.neulet.2004.04.053 |
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| Author | Search for: Eckert, Gunter P.; Search for: Keller, Jan-Henning; Search for: Jourdan, Claudia; Search for: Karas, Michael; Search for: Volmer, Dietrich A.1; Search for: Schubert-Zsilavecz, Manfred; Search for: Muller, Walter E. |
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| Affiliation | - National Research Council of Canada. NRC Institute for Marine Biosciences
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| Format | Text, Article |
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| Subject | Hypericum perforatum; St. John's Wort; hyperforin; brain; membrane; fluidity; HPLC; MS |
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| Abstract | Hyperforin, the major active constituent of St. John Wort (SJW) extract, affects several neurotransmitter systems in the brain putatively by modulation of the physical state of neuronal membranes. Accordingly, we tested the effects of SJW extract and of hyperforin on the properties of murine brain membrane fluidity. Oral administration of SJW extract and of hyperforin sodium salt results in significant hyperforin brain levels. Treatment of mice with hyperforin leads to decreased annular- and bulk fluidity and increased acyl-chain flexibility of brain membranes. All hyperforin related changes of membrane properties were significantly correlated with the corresponding hyperforin brain levels. Our data emphasises a membrane interaction of hyperforin that possibly contributes to its pharmacological effects. |
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| Publication date | 2004-09 |
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| Terms of use | - Copyright © 2004 Elsevier Ireland Ltd. All rights reserved.
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NRC number | 1684 |
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| NPARC number | 3538168 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 82a759f8-4a3e-4b77-a26d-c0a5762ba258 |
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| Record created | 2009-03-01 |
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| Record modified | 2020-04-17 |
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