Antiproliferative activity of the Netherlands propolis and its active principles in cancer cell lines

From National Research Council Canada

DOI	Resolve DOI: https://doi.org/10.1016/S0378-8741(02)00022-3
Author	Search for: Banskota, Arjun H.; Search for: Nagaoka, Takema; Search for: Sumioka, Lucia Yoshie; Search for: Tezuka, Yasuhiro; Search for: Awale, Suresh; Search for: Midorikawa, Kiyoshi; Search for: Matsushige, Katsumichi; Search for: Kadota, Shigetoshi
Format	Text, Article
Subject	Propolis; Antiproliferative activity; DPPH radical scavenging activity; Benzyl caffeate; Phenethyl caffeate; Cinnamyl caffeate
Abstract	The MeOH extract of the Netherlands propolis showed promising antiproliferative activity toward highly liver-metastatic murine colon 26-L5 carcinoma with an EC50 value of 3.5 μg/ml. Further, antiproliferative activity-guided purification of the MeOH extract led us to isolate four flavonoids (1–4), seven cinnamic acid derivatives (5–11) and two new glycerol derivatives (12, 13), whose structures were elucidated on the basis of spectral analysis. The isolated compounds were tested for their antiproliferative activity against murine colon 26-L5, murine B16-BL6 melanoma, human HT-1080 fibrosarcoma and human lung A549 adenocarcinoma cell lines. The benzyl (9), phenethyl (10) and cinnamyl caffeates (11) possessed potent antiproliferative activities with EC50 values of 0.288, 1.76 and 0.114 μM, respectively, toward colon 26-L5 carcinoma. These caffeates were considered to be active constituents of the Netherlands propolis in their antiproliferative activity. The antioxidative activity of these caffeates may play an important role in their antiproliferative activities.
Publication date	2002-04-01
In	Journal of Ethnopharmacology 80, no. 1 (1 April 2002): 67–73.
Language	English
Peer reviewed	Yes
NRC publication	This is a non-NRC publication "Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.
NPARC number	21274781
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Record identifier	7fb87261-ba85-46f0-9862-e3df2e38faf1
Record created	2015-04-08
Record modified	2020-03-30

Date modified:: 2024-11-12