Delphinidin, a dietary anthocyanidin, inhibits vascular endothelial growth factor receptor-2 phosphorylation

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DOIResolve DOI: https://doi.org/10.1093/carcin/bgi279
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Name affiliation
  1. National Research Council Canada. NRC Biotechnology Research Institute
FormatText
TypeArticle
Journal titleCarcinogenesis
ISSN0143-3334
1460-2180
Volume27
Issue5
Pages989–996; # of pages: 8
SubjectbFGF; basic fibroblast growth factor; Cy; cyanidin; Dp; delphinidin; Dp 3-glu; delphinidin 3- O -beta-glucopyranoside; EC; endothelial cell; ERK; extracellular-signal-regulated kinase; HUVEC; human umbilical vein endothelial cell; Mv; malvidin; Pg; pelargonidin; Pt; petunidin; STS; staurosporine; VEGF; vascular endothelial growth factor; VEGFR-2; vascular endothelial growth factor receptor-2
Abstract
Epidemiological studies have shown that a diet rich in fruits and vegetables has a beneficial preventive effect on cardiovascular diseases and cancer by mechanisms that have not yet been elucidated. In this work, we investigated the antiangiogenic activities of anthocyanidins, a class of polyphenols present at high levels in fruits. Among the tested anthocyanidins (cyanidin, delphinidin, malvidin, pelargonidin, peonidin and petunidin), delphinidin was the most potent angiogenic inhibitor. In vitro , low concentrations of delphinidin inhibited vascular endothelial growth factor (VEGF)-induced tyrosine phosphorylation of VEGF receptor (VEGFR)-2, leading to the inhibition of downstream signaling triggered by VEGFR-2. Inhibition of VEGFR-2 by delphinidin inhibited the VEGF-induced activation of ERK-1/2 signaling and the chemotactic motility of human EC as well as their differentiation into capillary-like tubular structures in Matrigel and within fibrin gels. In vivo , delphinidin was able to suppress basic fibroblast growth factor-induced vessel formation in the mouse Matrigel plug assay. The identification of delphinidin as a naturally occurring inhibitor of VEGF receptors suggests that this molecule possesses important antiangiogenic properties that may be helpful for the prevention and treatment of cancer.
Publication date
PublisherOxford University Press
Peer reviewedYes
NRC numberNRC-BRI-47792
NPARC number3538861
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Record created2009-03-01
Record modified2019-08-30
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