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Self-assembled rosette nanotubes from tetra guanine-cytosine modules

From National Research Council Canada

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DOIResolve DOI: https://doi.org/10.1039/D4NA00567H
AuthorSearch for: 1, 2ORCID identifier: https://orcid.org/0000-0001-5151-9484; Search for: 3, 2; Search for: 3, 2; Search for: 3; Search for: 3, 2, 4ORCID identifier: https://orcid.org/0000-0001-7629-7080
Affiliation
  1. National Research Council Canada. Human Health Therapeutics
  2. University of Alberta. Department of Chemistry
  3. National Research Council Canada. Nanotechnology
  4. University Mohammed VI Polytechnic
FunderSearch for: National Research Council Canada; Search for: University of Alberta
FormatText, Article
Abstract
Self-assembly of small molecules into supramolecular architectures is a sustainable alternative to new advanced material design. Herein, the design and synthesis of a self-assembling system containing four covalently linked hybrid guanine and cytosine (G∧C) units that were connected through bifunctional amines are reported. These tetra G∧C motifs were characterized and self-assembled in water and methanol to produce discrete nanostructures. Each module has 24 sites for intermolecular hydrogen bonding and it is proposed that in solution the four G∧C units per molecule align into a linear stack which in turn self-assembles into a hexameric super-helix held together by 72 intermolecular hydrogen bonds. Stacking of these nano-helices led to the formation of quad rosette nanotubes.
Publication date
PublisherRoyal Society of Chemistry
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  • Nanoscale Advances 7, no. 1 (27 November 2024): 281–287.
LanguageEnglish
Peer reviewedYes
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Record identifier7a7f2572-d30b-4043-8457-3b472c2ed5bd
Record created2025-02-19
Record modified2025-11-03
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