| DOI | Resolve DOI: https://doi.org/10.1016/j.phytochem.2014.11.021 |
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| Author | Search for: Lu, Yuping1; Search for: Van, Dang1; Search for: Deibert, Leah1; Search for: Bishop, Greg1; Search for: Balsevich, John1 |
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| Affiliation | - National Research Council of Canada. Aquatic and Crop Resource Development
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| Format | Text, Article |
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| Subject | Saponins; Saponaria officinalis L.; Caryophyllaceae; Quillaic acid; Gypsogenin; 2D NMR spectroscopy |
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| Abstract | Nine quillaic acid and five gypsogenin bisdesmosides were isolated from roots of Saponaria officinalis L. (Caryophyllaceae). Seven of the quillaic acid saponins possessed a 3-O-β-d-galactopyranosyl-(1 → 2)-[β-d-xylopyranosyl-(1 → 3)]-β-d-glucuronopyranosyl unit, but differed from each other in oligosaccharide units linked to the C-28 ester. The five gypsogenin saponins isolated from the roots all possessed the 3-O-β-d-galactopyranosyl-(1 → 2)-[β-d-xylopyranosyl-(1 → 3)]-β-d-glucuronopyranosyl unit, with their oligosaccharide units linked to the C-28 ester differing. Structures were elucidated by extensive 1D and 2D NMR spectroscopy and mass spectrometry. The saponins were evaluated for growth inhibitory activity in two human cancer cell lines and hemolytic activity in sheep red blood cells. |
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| Publication date | 2014-12-19 |
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| Publisher | Elsevier |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21275538 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 797fbd14-e338-47cd-9fdf-aad79a07729a |
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| Record created | 2015-07-14 |
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| Record modified | 2020-04-22 |
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