| DOI | Resolve DOI: https://doi.org/10.1016/j.jnutbio.2005.05.014 |
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| Author | Search for: Matchett, Michael D.; Search for: MacKinnon, Shawna L.1; Search for: Sweeney, Marva I.; Search for: Gottschall-Pass, Katherine T.; Search for: Hurta, Robert A. R. |
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| Affiliation | - National Research Council of Canada. Aquatic and Crop Resource Development
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| Format | Text, Article |
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| Subject | flavonoids; MMP; PKC; MAP kinase; blueberry; cells |
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| Abstract | Regulation of the matrix metalloproteinases (MMPs) is crucial to regulate extracellular matrix (ECM) proteolysis which is important in metastasis. This study investigated the mechanism(s) by which three flavonoid-enriched fractions from lowbush blueberry (Vaccinium angustifolium) down-regulate MMP activity in DU145 human prostate cancer cells. Metalloproteinase activity was evaluated from cells exposed to “crude,” anthocyanin-enriched (AN) and proanthocyanidin-enriched (PAC) fractions. Differential down-regulation of MMPs was observed. The activity of the endogenous tissue inhibitors of metalloproteinases (TIMPs) from these cells was also evaluated. Increases in TIMP-1 and TIMP-2 activity were observed in response to these fractions. The possible involvement of protein kinase C (PKC) and mitogen-activated protein (MAP) kinase pathways in the flavonoid-mediated decreases in MMP activity was observed. These findings indicate that blueberry flavonoids may use multiple mechanisms in down-regulating MMP activity in these cells. |
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| Publication date | 2006-02 |
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| Terms of use | - Copyright 2006 Elsevier Inc. All rights reserved
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NRC number | 1564 |
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| NPARC number | 3538548 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 6fcc3d5a-19bf-4ff8-88ad-8465e9e5551b |
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| Record created | 2009-03-01 |
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| Record modified | 2020-04-22 |
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