| DOI | Resolve DOI: https://doi.org/10.1039/c2jm31749d |
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| Author | Search for: Zhang, X. F.1; Search for: Mansouri, S.; Search for: Clime, L.; Search for: Ly, H. Q.; Search for: Yahia, L. 'H.; Search for: Veres, T.1 |
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| Affiliation | - National Research Council of Canada. Medical Devices
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| Format | Text, Article |
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| Abstract | We demonstrate a one-step procedure for the synthesis of Fe3O4–silica core–shell nanoparticles with hierarchically ultra-large pores independent of any post-treatment such as annealing and template-molecule removal. The nanoporous silica shells with available amine groups were functionalized by clickable linkers to produce pH-sensitive amides for regulating the release of an anti-cancer drug, doxorubicin (DOX). The loading amount of DOX reached up to 13.2 mg per 100 mg nanoparticles, 74.2% of which can be effectively released after 63 h at body temperature and pH 5 with decreased side effects. Such excellent features of these nanoparticles appear to arise from the integrated hierarchically ultra-large open-porosities and a homogeneous dispersibility in aqueous solution that has a great potential for their use as drug delivery systems. |
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| Publication date | 2012-05-09 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21268951 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 6ec18330-3207-467e-9dac-10ec3661b4d5 |
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| Record created | 2013-11-27 |
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| Record modified | 2020-04-21 |
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