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Metal-free, acid-catalyzed ortho -directed synthesis of anthranilic acid derivatives using carbodiimides

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DOIResolve DOI: https://doi.org/10.1021/acs.orglett.5b01160
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Affiliation
  1. National Research Council of Canada. Information and Communication Technologies
FormatText, Article
Abstract
One-pot syntheses of fluorescent o-aminobenzoates, o-aminopyridine carboxylates, and a 2′-amino-[1,1′-biphenyl]-2-carboxylic acid are described. Carbodiimides are used as the source of the 2-amino function which inserts onto an aromatic ring using S<inf>N</inf>Ar reaction conditions. This method proceeds regiospecifically with a range of 2-fluoroaromatic acids or esters bearing further aryl fluorine, trifluoromethyl, and cyano substituents.
Publication date
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  • Organic Letters 17, no. 11 (20 May 2015): 2744–2747.
LanguageEnglish
Peer reviewedYes
NPARC number21275769
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Record identifier68fd97c9-c27d-4c12-a5d4-a8514ca1d035
Record created2015-07-14
Record modified2020-06-04
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