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Infrared spectroscopy of exfoliated cervical cell specimens: proceed with caution

From National Research Council Canada

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Affiliation
  1. National Research Council of Canada. NRC Institute for Biodiagnostics
FormatText, Article
Subjectspectroscopy; cervix neoplasms; mass screening; Papanicolaou smear
Abstract
Objective: To determine whether diagnostic information may be recovered from the infrared spectra of exfoliated cell specimens by using a novel spectral feature extraction method, in conjunction with linear and quadratic discriminant analysis, for spectral classification. Study Design: Over 800 infrared spectra were included in the study, with corresponding clinical diagnoses based upon cytology and, when available, histology reports. Three sets of classification trials were carried out with the aim of distinguishing the spectra corresponding to normal specimens from CIN 1, 2 and 3. For each of these three cases, the procedure was to: (1) develop a set of provisional classification models using only a #training# subset of the spectra, and (2) test each provisional model by its ability to correctly predict the diagnoses on the basis of the remaining spectra. Results: For optimal classification trials, training set classification accuracies were 68% for normal/CIN 1, 73% for normal/CIN 2 and 81% for normal/CIN 3; for the corresponding test sets the classification accuracies were 60%, 60% and 67%, respectively. Conclusion: The infrared spectra of exfoliated cervical cells carry information regarding the presence or absence of dysplasia, and that information is recoverable#albeit imperfectly at this stage#from the spectra of #real life# cell preparations.
Publication date
PublisherThe International Academy of Cytology and the Italian Society of Urologic Pathology
Science Printers and Publishers
In
  • Analytical & Quantitative Cytology & Histology 21, no. 4 (August 1999): 292–302.
NotePMID: 10560506
Peer reviewedYes
NRC number944
NPARC number9148548
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Record identifier67465826-ec06-48c1-92cd-cbaf9e5b57c0
Record created2009-06-25
Record modified2024-02-21
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