| DOI | Resolve DOI: https://doi.org/10.1007/978-1-60761-454-8_11 |
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| Author | Search for: Brisson, Jean-Robert1; Search for: Vinogradov, Evgeny1; Search for: McNally, David J.1; Search for: Khieu, Nam Huan1; Search for: Schoenhofen, Ian C.1; Search for: Logan, Susan M.1; Search for: Jarrell, Harold1 |
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| Name affiliation | - National Research Council of Canada. NRC Institute for Biological Sciences
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| Format | Text, Book Chapter |
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| Subject | glycomic; glycans; polysaccharides; glycoanalysis; protein–carbohydrate; interactions; HR-MAS; NMR; structural analysis; molecular modeling |
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| Abstract | Glycomics which is the study of saccharides and genes responsible for their formation requires the continuous development of rapid and sensitive methods for the identification of glycan structures. It involves glycoanalysis which relies upon the development of methods for determining the structure and interactions of carbohydrates. For the application of functional glycomics to microbial virulence, carbohydrates and their associated metabolic and carbohydrate processing enzymes and respective genes can be identified and exploited as targets for drug discovery, glyco-engineering, vaccine design, and detection and diagnosis of diseases. Glycomics also encompasses the detailed understanding of carbohydrate–protein interactions and this knowledge can be applied to research efforts focused toward the development of vaccines and immunological therapies to alleviate infectious diseases. |
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| Publication date | 2009-10-31 |
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| Publisher | Springer |
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| In | |
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| Series | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 23002069 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction |
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| Record identifier | 62137941-28b6-4bfc-a20e-f33793e6aaad |
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| Record created | 2017-08-04 |
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| Record modified | 2020-06-17 |
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