Ionspray mass spectrometry of marine toxins. IV. Determination of diarrhetic shellfish poisoning toxins in mussel tissue by liquid chromatography/mass spectrometry

From National Research Council Canada

DOIResolve DOI: http://doi.org/10.1002/rcm.1290060210
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Name affiliation
  1. National Research Council Canada. NRC Institute for Marine Biosciences
TypeArticle
Journal titleRapid Communications in Mass Spectrometry
ISSN0951-4198
1097-0231
Volume6
Issue2
Pages121–127
Abstract
An improved liq. chromatog./mass spectrometric (LC/MS) method utilizing gradient elution and ion-spray ionization is described for the sensitive detn. of okadaic acid and dinophysistoxin-1, the principal toxins implicated in cases of diarrhetic shellfish poisoning. The method was used to confirm the presence of both toxins, together with a recently identified isomer of okadaic acid, dinophysistoxin-2, in various samples of cultivated blue mussels (Mytilus edulis) from Canadian and European waters. The method provided a mass detection limit of 0.4 ng for each toxin, thus allowing detection of 40 ng per g of whole mussel tissue (or approx. 10 ng/g if only the digestive glands were used in the assay). Quant. results obtained by LC/MS were in good agreement with those obtained by derivatization and high-performance liq. chromatog. with fluorescence detection.
Publication date
LanguageEnglish
Peer reviewedYes
NPARC number23001065
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Record identifier5d61458e-ce24-4369-8580-7e21b1c48b88
Record created2016-12-07
Record modified2016-12-07
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