National Research Council of Canada. Medical Devices
25th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2021), Oct. 10-14, 2021, Palm Springs, California [paired with a virtual conference site hosted on-line]
blood fractionation; centrifugal microfluidics; active pneumatic pumping; world-to-chip interface
A fully automated microfluidic cartridge for efficient and high-throughput isolation of PBMCs with high viability and purity is presented. The proposed approach uses a centrifugal microfluidic platform with pneumatic actuation and world-to-chip interfacing for accurate control of blood fractionation processes, allowing precise metering and extraction of PBMCs from large volumes of blood samples in a sequential manner. The disposable passive cartridges were fabricated in standard thermoplastic polymers, which allows future use of scalable manufacturing methods suitable for industrial translation.
Chemical and Biological Microsystems Society
25th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2021), W4A-521.c (August 2022): 953–954.