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CHO cells for virus-like particle and subunit vaccine manufacturing

From National Research Council Canada

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DOIResolve DOI: https://doi.org/10.1016/j.vaccine.2024.03.034
AuthorSearch for: 1; Search for: 1; Search for: 1ORCID identifier: https://orcid.org/0009-0002-4403-0677; Search for: 1ORCID identifier: https://orcid.org/0000-0002-2268-4111
Affiliation
  1. National Research Council Canada. Human Health Therapeutics
FunderSearch for: Natural Sciences and Engineering Research Council of Canada; Search for: National Research Council Canada
FormatText, Article
SubjectChinese hamster ovary cells; vaccine production; subunit vaccines; virus-like particle; viral clearance; endogenous retrovirus-like particles
Abstract
Chinese Hamster Ovary (CHO) cells, employed primarily for manufacturing monoclonal antibodies and other recombinant protein (r-protein) therapeutics, are emerging as a promising host for vaccine antigen production. This is exemplified by the recently approved CHO cell-derived subunit vaccines (SUV) against respiratory syncytial virus (RSV) and varicella-zoster virus (VZV), as well as the enveloped virus-like particle (eVLP) vaccine against hepatitis B virus (HBV). Here, we summarize the design, production, and immunogenicity features of these vaccine and review the most recent progress of other CHO-derived vaccines in pre-clinical and clinical development. We also discuss the challenges associated with vaccine production in CHO cells, with a focus on ensuring viral clearance for eVLP products.
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PublisherElsevier
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  • Vaccine 42, no. 10 (19 March 2024): 2530–2542.
LanguageEnglish
Peer reviewedYes
IdentifierS0264410X24003219
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Record identifier58dcdb85-004e-46bd-8fc1-468a6a9102d1
Record created2024-09-10
Record modified2025-11-03
Date modified: