| DOI | Resolve DOI: https://doi.org/10.3109/10715769009109672 |
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| Author | Search for: Burton, G.W.1; Search for: Ingold, K. U.1; Search for: Cheeseman, K.H.; Search for: Slater, T.F. |
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| Affiliation | - National Research Council of Canada
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| Format | Text, Article |
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| Subject | alpha tocopherol; vitamin binding protein; animal experiment; animal tissue; bioavailability; conference paper; liver; rat; tumor cell; antioxidants; biological availability; cell division; comparative study; deuterium; guinea pigs; lipid peroxidation; liver; liver regeneration; oxidation-reduction; rat; stereoisomerism; support, non-U. S. Gov't; vitamin E; animalia |
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| Abstract | αTocopherol, a superior chain-breaking, peroxyl radical-trapping antioxidant and the most active component of vitamin E, is elevated in liver tumor cells, contributing to their greater resistance towards lipid peroxidation compared to cells from normal tissues. Also, in regenerating rat liver the level of vitamin E has been found to fluctuate in phase with the rate of cell division. In order to study the biokinetcis and mechanisms of the distribution of vitamin E in organs and within tissues of animals, deuterated forms of αtocopherol have been synthesized and their uptake into blood and tissues has been measured by gas chromatography-mass spectrometry. Measurement of the competitive uptake from a mixture of the RRR-and SRR-αtocopherol stereoisomers labelled with different amounts of deuterium shows that the liver exerts a strong preference for secretion of the natural (RRR) stereoisomer into the plasma. It is suggested that a tocopherol-binding protein plays a key role in this process. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |
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| Publication date | 1990 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21276574 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 57cf4db1-9eb8-4fe7-980e-eeb0647aac54 |
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| Record created | 2015-10-13 |
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| Record modified | 2020-03-17 |
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