Application of deuterated a-tocopherols to the biokinetics and bioavailability of vitamin e

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.3109/10715769009109672
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  1. National Research Council Canada
FormatText
TypeArticle
Journal titleFree Radical Research
ISSN1071-5762
Volume11
Issue1-Mar
Pages99–107; # of pages: 9
Subjectalpha tocopherol; vitamin binding protein; animal experiment; animal tissue; bioavailability; conference paper; liver; nonhuman; rat; tumor cell; Animal; Antioxidants; Biological Availability; Cell Division; Comparative Study; Deuterium; Guinea Pigs; Human; Lipid Peroxidation; Liver; Liver Regeneration; Oxidation-Reduction; Rats; Stereoisomerism; Support, Non-U.S. Gov't; Vitamin E; Animalia
Abstract
αTocopherol, a superior chain-breaking, peroxyl radical-trapping antioxidant and the most active component of vitamin E, is elevated in liver tumor cells, contributing to their greater resistance towards lipid peroxidation compared to cells from normal tissues. Also, in regenerating rat liver the level of vitamin E has been found to fluctuate in phase with the rate of cell division. In order to study the biokinetcis and mechanisms of the distribution of vitamin E in organs and within tissues of animals, deuterated forms of αtocopherol have been synthesized and their uptake into blood and tissues has been measured by gas chromatography-mass spectrometry. Measurement of the competitive uptake from a mixture of the RRR-and SRR-αtocopherol stereoisomers labelled with different amounts of deuterium shows that the liver exerts a strong preference for secretion of the natural (RRR) stereoisomer into the plasma. It is suggested that a tocopherol-binding protein plays a key role in this process. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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LanguageEnglish
Peer reviewedYes
NPARC number21276574
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