| Download | - View supplementary information: Controlled chitosan molecular weight reduction by mechanochemical and aging-based phosphoric acid hydrolysis (PDF, 5.6 MiB)
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| DOI | Resolve DOI: https://doi.org/10.1021/acssuschemeng.3c00367 |
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| Author | Search for: Yang, Galen; Search for: Lam, Edmond1ORCID identifier: https://orcid.org/0000-0003-4343-4469; Search for: Moores, AudreyORCID identifier: https://orcid.org/0000-0003-1259-913X |
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| Affiliation | - National Research Council of Canada. Aquatic and Crop Resource Development
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| Funder | Search for: National Research Council Canada; Search for: Fonds de Recherche du Quebec. Nature et Technologies; Search for: Canada Foundation for Innovation; Search for: Natural Sciences and Engineering Research Council of Canada; Search for: McGill University |
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| Format | Text, Article |
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| Subject | chitosan; mechanochemistry; aging; polydispersity; molecular weight; gel permeation chromatography; hydrolysis |
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| Abstract | Chitosan is typically produced by the deacetylation of the chitin biopolymer. Its molecular weight (Mw) is a function of the chitin source and the deacetylation conditions. It remains a challenge to both control the Mw of chitosan and obtain good monodispersity, which are essential for optimal function of chitosan in different applications. This study explores the use of mechanochemistry and aging as effective methods toward the controlled reduction of the Mw of commercial high Mw chitosan (HMwChs) with phosphoric acid, where Mw was measured by gel permeation chromatography (GPC). In comparison to conventional solution-based methods, this new mechanochemical method features improved process mass intensity in comparison to conventional techniques and affords low Mw chitosan (LMwChs) samples in a range of 200 to 19.5 kDa, with a polydispersity down to1.8. |
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| Publication date | 2023-05-05 |
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| Publisher | American Chemical Society |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 55feb987-2e07-42e8-81bc-6545d31b67a2 |
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| Record created | 2023-09-11 |
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| Record modified | 2023-09-11 |
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