Uncertainty evaluation in normalization of isotope delta measurement results against international reference materials

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DOIResolve DOI: https://doi.org/10.1007/s00216-017-0659-1
AuthorSearch for: 1ORCID identifier: https://orcid.org/0000-0002-3349-5535; Search for: 1
Name affiliation
  1. National Research Council of Canada. Measurement Science and Standards
FormatText, Article
Journal titleAnalytical and Bioanalytical Chemistry
ISSN1618-2642
1618-2650
Volume410
Issue3
Pages1061–1069
Subjectisotope delta; normalization; uncertainty evaluation; random effects model
Abstract
Isotope delta measurements are normalized against international reference standards. Although multi-point normalization is becoming a standard practice, the existing uncertainty evaluation practices are either undocumented or are incomplete. For multi-point normalization, we present errors-in-variables regression models for explicit accounting of the measurement uncertainty of the international standards along with the uncertainty that is attributed to their assigned values. This manuscript presents framework to account for the uncertainty that arises due to a small number of replicate measurements and discusses multi-laboratory data reduction while accounting for inevitable correlations between the laboratories due to the use of identical reference materials for calibration. Both frequentist and Bayesian methods of uncertainty analysis are discussed.
Publication date
PublisherSpringer
LanguageEnglish
Peer reviewedYes
IdentifierABC-01162-2017
NPARC number23002713
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Record modified2020-06-04
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