National Research Council of Canada. Human Health Therapeutics
International Federation of Placental Associations Conference (IFPA EPG 2014), Sept 9-12, 2014, Paris, France
Pregnancy confers increased susceptibility to intracellular infections such as Salmonella enterica serovar Typhimurium (S. Tm). S. Tm infection during pregnancy in normally resistant mice (129X1/SvJ with a fully functional Nramp gene) leads to rapid severe placental inflammation followed by fetal and maternal death. However, the immune mechanism of feto-maternal interface inflammation has not been fully elucidated. The objective of this study was to test the hypothesis that the mechanism of trophoblast (TBC) cell death following infection, contributes to feto-maternal inflammation and adverse effects on the mother and fetus.