| DOI | Resolve DOI: https://doi.org/10.1016/0304-4165(87)90155-3 |
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| Author | Search for: Wayner, D.D.M.1; Search for: Burton, G.W.1; Search for: Ingold, K. U.1; Search for: Barclay, L.R.C.; Search for: Locke, S.J. |
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| Affiliation | - National Research Council of Canada
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| Format | Text, Article |
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| Subject | alpha tocopherol; antioxidant; ascorbic acid; free radical; lipid peroxide; perhydroxyl radical; peroxide; plasma protein; uric acid; biosynthesis; blood; physiology; solubility; Antioxidants; Ascorbic Acid; Blood Proteins; Free Radicals; Lipid Peroxides; Peroxides; Solubility; Support, Non-U.S. Gov't; Uric Acid; Vitamin E |
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| Abstract | The Total (Peroxyl) Radical-trapping Antioxidant Parameter (TRAP) of six freshly prepared human plasma samples and 45 frozen plasma samples has been determined. It is shown that contributions from urate (35-65%), plasma proteins (10-50%), ascorbate (0-24%) and vitamin E (5-10%) to TRAP account for all of the peroxyl radical-trapping antioxidant activity in the majority of the samples. The changes in concentrations of the plasma antioxidants during peroxyl radical attack show that first line of defense is provided by the plasma sulfhydryl group, even urate being spared during the initial stages of the reaction. The modes of action of all of these plasma antioxidants and possible interactions between them are discussed, with particular emphasis on the abilities of the water-soluble antioxidants to regenerate or spare the only lipid-soluble antioxidant, vitamin E. © 1987. |
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| Publication date | 1987 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21276506 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 45c4fb8a-832f-4d4d-ad8b-63c2933ef815 |
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| Record created | 2015-10-13 |
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| Record modified | 2020-03-17 |
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