Antimalarial activity of cassane- and norcassane-type diterpenes from Caesalpinia crista and their structure–activity relationship

From National Research Council Canada

DOI	Resolve DOI: https://doi.org/10.1248/bpb.29.1050
Author	Search for: Kalauni, Surya Kant; Search for: Awale, Suresh; Search for: Tezuka, Yasuhiro; Search for: Banskota, Arjun Hari; Search for: Linn, Thein Zaw; Search for: Asih, Puji Budi Setia; Search for: Syafruddin, Din; Search for: Kadota, Shigetoshi
Format	Text, Article
Abstract	Malaria is one of the most life-threatening infectious diseases worldwide and claims the millions of peoples life each year. The appearance of drug-resistance Plasmodium falciparum has made the treatment of malaria increasingly problematic, and thus, it is a dire need to search the new alternatives of current drugs. In the present study, 44 cassane- and norcassane-type diterpenes isolated from Caesalpinia crista of Myanmar and Indonesia were evaluated for their antimalarial activity against the malaria parasite Plasmodium falciparum FCR-3/A2 clone in vitro. Most of the tested diterpenes displayed antimalarial activity, and norcaesalpinin E (28) showed the most potent activity with an IC50 value of 0.090 μM, more potent than the clinically used drug chloroquine (IC50, 0.29 μM). Based on the observed results, a structure–activity relationship has been established.
Publication date	2006
In	Biological and Pharmaceutical Bulletin 29, no. 5 (2006): 1050–1052.
Language	English
Peer reviewed	Yes
NRC publication	This is a non-NRC publication "Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.
NPARC number	21274262
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Record identifier	4537223a-9371-4ce7-bb6a-1653fbf4a675
Record created	2015-03-06
Record modified	2020-04-22

Date modified:: 2024-07-11