| DOI | Resolve DOI: https://doi.org/10.1016/0014-2999(87)90514-0 |
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| Author | Search for: Dresel, Peter E.; Search for: Knickle, Leah1 |
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| Name affiliation | - National Research Council Canada. Aquatic and Crop Resource Development
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| Format | Text |
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| Type | Article |
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| Journal title | European Journal of Pharmacology |
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| ISSN | 0014-2999 |
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| Volume | 144 |
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| Issue | 2 |
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| Pages | 153–157 |
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| Subject | Aorta; Cytochalasin-B; EDRF; Histamine; Noradrenaline; Phloretin; Sugar transport; (Contraction, Relaxation) |
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| Abstract | Cytochalasin-B (20 μM) and phloretin (100 μM) blocked by more than 80% the contractile responses to calcium ions in partially depolarized rabbit aortic strips. Both also blocked, but only by approximately 50%, the responses to noradrenaline and histamine in normal calcium medium. The responses to these agonists in calcium-free EGTA medium were also blocked partially. Cytochalasin-B partially blocked the acetylcholine-induced relaxation of aortic strips precontracted with phenylephrine but not the relaxation due to nitroglycerine or compound A 23187. The relaxation due to isoprenaline was potentiated by cytochalasin B. Since both compounds are known to block hexose transport but share no other known effects, it is suggested that a glycolytic intermediate could be required for the contraction in response to calcium. However, the concentrations of cytochalasin-B required for these effects were somewhat greater than those usually required to block hexose transport. |
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| Publication date | 1987-12 |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 23000932 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction |
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Record identifier | 4426b491-aa17-46a1-a7f6-6a3efbd55cb4 | | Record created | 2016-11-17 |
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| Record modified | 2016-11-17 |
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