| DOI | Resolve DOI: http://doi.org/10.1016/0014-2999(87)90514-0 |
|---|
| Author | Search for: Dresel, Peter E.; Search for: Knickle, Leah1 |
|---|
| Name affiliation | - National Research Council Canada. Aquatic and Crop Resource Development
|
|---|
| Type | Article |
|---|
| Journal title | European Journal of Pharmacology |
|---|
| ISSN | 0014-2999 |
|---|
| Volume | 144 |
|---|
| Issue | 2 |
|---|
| Pages | 153–157 |
|---|
| Subject | Aorta; Cytochalasin-B; EDRF; Histamine; Noradrenaline; Phloretin; Sugar transport; (Contraction, Relaxation) |
|---|
| Abstract | Cytochalasin-B (20 μM) and phloretin (100 μM) blocked by more than 80% the contractile responses to calcium ions in partially depolarized rabbit aortic strips. Both also blocked, but only by approximately 50%, the responses to noradrenaline and histamine in normal calcium medium. The responses to these agonists in calcium-free EGTA medium were also blocked partially. Cytochalasin-B partially blocked the acetylcholine-induced relaxation of aortic strips precontracted with phenylephrine but not the relaxation due to nitroglycerine or compound A 23187. The relaxation due to isoprenaline was potentiated by cytochalasin B. Since both compounds are known to block hexose transport but share no other known effects, it is suggested that a glycolytic intermediate could be required for the contraction in response to calcium. However, the concentrations of cytochalasin-B required for these effects were somewhat greater than those usually required to block hexose transport. |
|---|
| Publication date | 1987-12 |
|---|
| Language | English |
|---|
| Peer reviewed | Yes |
|---|
| NPARC number | 23000932 |
|---|
| Export citation | Export as RIS |
|---|
| Report a correction | Report a correction |
|---|
Record identifier | 4426b491-aa17-46a1-a7f6-6a3efbd55cb4 | | Record created | 2016-11-17 |
|---|
| Record modified | 2016-11-17 |
|---|
