| DOI | Resolve DOI: https://doi.org/10.1111/j.1574-695X.2008.00416.x |
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| Author | Search for: Altman, Eleonora1; Search for: Chandan, Vandana1; Search for: Larocque, Suzon1; Search for: Aubry, Annie1; Search for: Logan, Susan M.1; Search for: Vinogradov, Evgeny1; Search for: Li, Jianjun1 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Biological Sciences
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| Format | Text, Article |
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| Subject | Helicobacter pylori; lipopolysaccharide; structure; colonization |
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| Abstract | The outer core region of Helicobacter pylori lipopolysaccharide of the majority of isolates contains an a-1,6-glucan polymer synthesized by the product of the HP0159 ORF. Structural studies carried out on HP0159 lipopolysaccharide mutants by a combination of chemical methods, mass spectrometry and nuclear magnetic resonance spectroscopy confirmed that insertional inactivation of HP0159 gene in H. pylori strains 26695 and SS1 resulted in formation of a truncated lipopolysaccharide molecule characterized by the presence of a terminal DD-heptose residue in the side-chain outer core fragment and maintaining an inner core backbone structure compared with the wild-type Lewis antigen-expressing strains. Colonization studies with HP0159 mutants of two mouse-colonizing strains, SS1 and M6, confirmed their inability to successfully colonize the murine stomach. |
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| Publication date | 2008-06-28 |
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| In | |
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| Language | English |
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| NRC number | ALTMAN2008A |
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| NPARC number | 9362157 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 3a65e533-129e-488d-ba8f-96b89270327f |
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| Record created | 2009-07-10 |
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| Record modified | 2020-04-15 |
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