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Nanotemplating for two-dimensional molecular imprinting

DOIResolve DOI: https://doi.org/10.1021/la063562q
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Affiliation
  1. National Research Council Canada. NRC Institute for Microstructural Sciences
  2. National Research Council Canada. NRC Institute for Chemical Process and Environmental Technology
FormatText, Article
Abstract
A new 2D molecular imprinting technique based on nanotemplating and soft-lithography techniques is reported. This technique allows the creation of target-specific synthetic recognition sites on different substrates using a uniquely oriented and immobilized template and the attachment of a molecularly imprinted polymer on a substrate. The molecularly imprinted polymer was characterized by AFM, fluorescence microscopy, and ATR-FTIR. We evaluated the rebinding ability of the sites with theophylline (the target molecule). The selectivity of the molecularly imprinted polymer was determined for the theophylline−caffeine couple. The molecularly imprinted polymer exhibited selectivity for theophylline, as revealed by competitive rebinding experiments. Fluorescence microscopy experiments provided complementary proof of the selectivity of the molecularly imprinted polymer surfaces toward theophylline. These selective molecularly imprinted polymers have the potential for chemical sensor applications. Because of its 2D nature, this novel chemical sensor technology can be integrated with many existing high-sensitivity multichannel detection technologies.
Date published
In
  • Langmuir 23, no. 10 (4 April 2007): 5452–5458.
LanguageEnglish
Peer reviewedYes
NPARC number20154424
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Record identifier391f1f93-9def-48ea-bd16-e9beca77f7f9
Record created2012-06-22
Record modified2020-05-10

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