| DOI | Resolve DOI: https://doi.org/10.1016/j.fsi.2005.11.004 |
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| Author | Search for: Dacanay, Andrew1; Search for: Bentley, B. Erin2; Search for: Brown, Laura L.1; Search for: Roberts, Amanda J.1; Search for: Johnson, Stewart C.1 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Marine Biosciences
- National Research Council of Canada. NRC Institute for Nutrisciences and Health
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| Format | Text, Article |
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| Subject | immunoglobulin; quaternary structure; gadid; haddock; cod |
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| Abstract | Tetrameric immunoglobulin (lg) in most teleosts is a fully disulphide cross-linked molecule. The multimeric lg from four species from the order Gadiformes; haddock (Melanogrammus aeglefinus L.), Atlantic cod (Gadus morhua L), pollock (Pollachius pollachius L.) and tusk (Brosme bromse A.) was examined by denaturing, non-reducing gel electrophoresis and gel filtration chromatography. Despite having a native molecular mass equivalent to that of other tetrameric teleost lg, gadid lg was never observed to exist as a fully disulphide cross-linked molecule; existing instead as a covalently cross-linked trimer with a non-covalently associated monomer. It is unknown whether this unique cross-linking is associated with the limited or absent specific humoral responses reported for members of this order. |
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| Publication date | 2006-08 |
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| Terms of use | |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NRC number | 1492 |
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| NPARC number | 3538560 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 31d22603-e2e7-4357-a8b7-75539fd6f594 |
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| Record created | 2009-03-01 |
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| Record modified | 2020-04-22 |
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