The knowledge base for cold spray has grown significantly in recent years and advances in the technology have shown viability for the process for titanium-based materials. For titanium and its alloys, the capability to rapidly produce thick, unoxidized deposits in open air makes cold spray a particularly attractive process. Here, selected results from the available literature are discussed to highlight key practical and fundamental aspects in cold-spray processing of titanium-base powders. An overview is presented for the general process and its underlying particle deformation and bonding mechanisms. The properties of cold-sprayed titanium material are characterized and process–microstructure–property relationships reviewed. Coating and additive manufacturing applications are then briefly outlined with a discussion of practical considerations. In the concluding remarks, views are offered on the current status and possible future directions of development for the technology.