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| DOI | Resolve DOI: https://doi.org/10.1016/j.chembiol.2019.03.018 |
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| Author | Search for: Tong, Wenyong; Search for: Maira, Mario; Search for: Roychoudhury, Rajarshi; Search for: Galan, Alba; Search for: Brahimi, Fouad; Search for: Gilbert, Michel1; Search for: Cunningham, Anna-Maria1; Search for: Josephy, Sylvia; Search for: Pirvulescu, Iulia; Search for: Moffett, Serge; Search for: Saragovi, H. Uri |
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| Affiliation | - National Research Council of Canada. Human Health Therapeutics
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| Format | Text, Article |
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| Subject | ganglioside; glycomimetic; immunity; vaccine; cancer therapy |
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| Abstract | Immune targeting of (glyco)protein tumor markers has been useful to develop cancer and virus vaccines. However, the ganglioside family of tumor-associated glycolipids remains intractable to vaccine approaches. Here we show that synthetic antigens mimicking the carbohydrate moiety of GD2 or GD3 gangliosides can be used as vaccines to activate a selective humoral and cellular immunity that is therapeutic against several cancers expressing GD2 or GD3. Adoptive transfer of T cells generated after vaccination elicits tumor-infiltrating lymphocytes of the γδ T cell receptor and CD8⁺ phenotypes; and affords a high therapeutic index. The glycomimetic vaccine principles can be expanded to target the family of tumor gangliosides and other carbohydrates expressed primarily in pathological states. |
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| Publication date | 2019-05-16 |
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| Publisher | Elsevier
Cell Press |
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| Licence | |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NRC number | NRC-HHT_53421 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 20aa9f9e-4b76-4246-8cb4-3dd6e091ba2a |
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| Record created | 2020-12-08 |
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| Record modified | 2021-09-24 |
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