Lipopolysaccharide structure of Helicobacter pylori serogroup O:3

DOI	Resolve DOI: https://doi.org/10.1016/j.carres.2013.03.008
Author	Search for: Altman, Eleonora¹; Search for: Chandan, Vandana¹; Search for: Li, Jianjun¹; Search for: Vinogradov, Evgeny¹
Name affiliation	National Research Council of Canada. Human Health Therapeutics
Format	Text, Article
Subject	Helicobacter pylori; LPS; Structure; NMR; MS
Abstract	In this study, we describe a re-investigation of the lipopolysaccharide structure of Helicobacter pylori serogroup O:3. Application of NMR and MS approaches to the analysis of oligosaccharides obtained through degradation of LPS from H. pylori serogroup O:3 by various methods confirmed that its general architecture was identical to that of LPS from H. pylori strains 26695 and SS1 and followed a sequential linear assembly of the α-1,6-glucan, dd-heptan, and O-chain components. Additionally, MALDI-MS analysis demonstrated that a significant proportion of H. pylori serogroup O:3 LPS was terminated with α-1,6-glucan and was not further substituted by dd-heptan and the O-chain polysaccharide.
Publication date	2013-03-16
Publisher	Elsevier
In	Carbohydrate Research 378: 139–143.
Language	English
Peer reviewed	Yes
Identifier	S0008621513000876
NPARC number	23000553
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Record identifier	1d9d8173-a6e0-4886-a6c5-88d24cb99837
Record created	2016-07-29
Record modified	2020-10-30