| DOI | Resolve DOI: https://doi.org/10.1016/S0009-8981(01)00796-3 |
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| Author | Search for: Sowa, Michael G.1; Search for: Matas, Anna1; Search for: Schattka, Bernhard J.1; Search for: Mantsch, Henry H.1 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Biodiagnostics
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| Format | Text, Article |
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| Subject | In vivo spectroscopy; Skin perfusion; Tissue oxygenation; Pressure ulcers; Blanch response; Projection operators |
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| Abstract | Background: For individuals with lightly pigmented skin, early stage pressure ulcers appear as areas of redness, which have compromised microcirculation and do not blanch in response to pressure. The lack of a visible blanch (hemodynamic response) to pressure is a convenient diagnostic test for stage I sores. However, the blanch response is not visually apparent in people with highly pigmented skin color due to the overwhelming contribution of melanin to the reflectance of skin. Methods: A simple least squares projection operator method is described, which can separate the reflectance contributions from melanin and hemoglobin. The methodology was tested in a study population of 20 subjects with healthy skin. The study population was evenly divided into a lightly pigmented skin group (visible blanch response) and a highly pigmented skin group (no visible blanch response). Results: The hemodynamic response to pressure being applied to the skin could clearly be distinguished spectroscopically in both groups at a high level of statistical significance. Conclusion: The specific aim of this work was directed towards developing a spectroscopic basis for distinguishing the healthy blanch response in a manner that was independent of skin pigmentation. However, the technique has a general application when optical hemodynamic measurements are being made over a diverse patient population or under conditions of varying pigmentation such as the seasonal changes in skin color. |
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| Publication date | 2002 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NRC number | 1944 |
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| NPARC number | 9148021 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 170eb1e7-cc32-469c-a7fe-e7d3fe7012f4 |
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| Record created | 2009-06-25 |
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| Record modified | 2020-03-30 |
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