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A new member of the troponin C superfamily: comparison of the primary structures of rat oncomodulin and rat parvalbumin

From National Research Council Canada

Alternative titleA new member of the troponin C superfamily - comparison of the primary structures of rat oncomodulin and rat parvalbumin
DOIResolve DOI: https://doi.org/10.1007/BF01121034
AuthorSearch for: 1; Search for: 1; Search for: 1
Affiliation
  1. National Research Council of Canada
FormatText, Article
Subjectisoelectric point; primary structure; tumour protein; extensive homology; homologous position
Abstract
When the amino-acid sequence of the 108-residue, rat tumour calcium-binding protein, oncomodulin, was aligned with that of rat muscle parvalbumin, 55 homologous positions were found, with an additional 33 single base-pair substitutions. This extensive homology, with virtual identity of the calcium-binding domains, signalled oncomodulin to be a member of the troponin C superfamily. The presence of Cys-18 and Phe-66 in oncomodulin, plus its isoelectric point of 3.9) suggest that this tumour protein is a 8-parvaJbumin, rather than a muscle α-parvalbumin.
Publication date
PublisherSpringer
In
  • Bioscience Reports 3: 1071–1075.
LanguageEnglish
Peer reviewedYes
IdentifierNRC-IBS-MACMANUS1983C
NPARC number9372159
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Record identifier14fad3c8-19ee-48cd-ba9b-d1036a935e0b
Record created2009-07-10
Record modified2020-05-19
Date modified: