| DOI | Resolve DOI: https://doi.org/10.1021/ac5005635 |
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| Author | Search for: Mostaço-Guidolin, L.B.1; Search for: Kohlenberg, E.K.1; Search for: Smith, M.1; Search for: Hewko, M.1; Search for: Major, A.; Search for: Sowa, M.G.1; Search for: Ko, A.C.-T.1 |
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| Affiliation | - National Research Council Canada. Medical Devices
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| Format | Text, Article |
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| Subject | Blood vessels; Optical correlation; Atherosclerotic lesions; Atherosclerotic plaque; Fluorescence imaging; Microscopic image; Non-linear optical; Numerical matrices; Positive correlations; Quantitative approach; Diseases |
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| Abstract | Quantification of atherosclerosis has been a challenging task owing to its complex pathology. In this study, we validated a quantitative approach for assessing atherosclerosis progression in a rabbit model using a numerical matrix, optical index for plaque burden, derived directly from the nonlinear optical microscopic images captured on the atherosclerosis-affected blood vessel. A positive correlation between this optical index and the severity of atherosclerotic lesions, represented by the age of the rabbits, was established based on data collected from 21 myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits with age ranging between new-born and 27 months old. The same optical index also accurately identified high-risk locations for atherosclerotic plaque formation along the entire aorta, which was validated by immunohistochemical fluorescence imaging. © 2014 American Chemical Society. |
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| Date published | 2014 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21272255 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 1439c653-f05f-41c4-aa7a-83b776fb6e16 |
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| Record created | 2014-07-23 |
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| Record modified | 2020-04-22 |
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