| DOI | Resolve DOI: https://doi.org/10.1016/j.bmcl.2004.08.018 |
|---|
| Author | Search for: Yannopoulos, Constantin G.; Search for: Xu, Ping1; Search for: Ni, Feng1; Search for: Chan, Laval; Search for: Pereira, Oswy Z.; Search for: Reddy, T. Jagadeeswar; Search for: Das, Sanjoy K.; Search for: Poisson, Carl; Search for: Nguyen-Ba, Nghe; Search for: Turcotte, Nathalie; Search for: Proulx, Melanie; Search for: Halab, Lilanne; Search for: Wang, Wuyi; Search for: Bédard, Jean; Search for: Morin, Nicolas; Search for: Hamel, Martine; Search for: Nicolas, Olivier; Search for: Bilimoria, Darious; Search for: L'Heureux, Lucille; Search for: Bethel, Richard; Search for: Dionne, Gervais |
|---|
| Affiliation | - National Research Council Canada. NRC Biotechnology Research Institute
|
|---|
| Format | Text, Article |
|---|
| Subject | pharmaceutical; polymerase-bound; sulfonamide |
|---|
| Abstract | HCV NS5B RNA-dependent RNA polymerase (NS5B) is essential for viral replication and is therefore considered a target for antiviral drug development. From our ongoing screening effort in the search for new anti-HCV agents, a novel inhibitor 1 with low lM activity against the HCV NS5B polymerase was identified. SAR analysis indicated the optimal substitution pattern required for activity, for example, carboxylic acid group at 2-position of thiophene ring. We describe the steps taken to identify and solve the bioactive conformation of derivative 6 through the use of the transferred NOE method (trNOE). |
|---|
| Publication date | 2004 |
|---|
| In | |
|---|
| Language | English |
|---|
| NRC number | 46236 |
|---|
| NPARC number | 3539714 |
|---|
| Export citation | Export as RIS |
|---|
| Report a correction | Report a correction (opens in a new tab) |
|---|
| Record identifier | 0d8b0768-2b37-4296-b1de-548dfaaab3c4 |
|---|
| Record created | 2009-03-01 |
|---|
| Record modified | 2020-04-17 |
|---|
