| Download | - View final version: In vivo anticancer activity of maesopsin 4-O-β-glucoside isolated from leaves of Artocarpus tonkinensis A. Chev. Ex Gagnep (PDF, 770 KiB)
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| DOI | Resolve DOI: https://doi.org/10.1016/j.apjtm.2016.03.012 |
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| Author | Search for: Thuy, Trinh Thi; Search for: Thien, Dao Duc; Search for: Quang Hung, Tran; Search for: Tam, Nguyen Thanh; Search for: Anh, Nguyen Thi Hoang; Search for: Nga, Nguyen Thi; Search for: Cuc, Nguyen Thi; Search for: Mai, Le Phuong1; Search for: Van Sung, Tran; Search for: Delfino, Domenico V.; Search for: Thao, Do Thi |
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| Affiliation | - National Research Council of Canada
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| Format | Text, Article |
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| Subject | Artocarpus tonkinensis; BALB/c; Hematological parameters; Lewis lung carcinoma; Maesopsin 4-O-β-glucoside |
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| Abstract | OBJECTIVE:
To investigate the antitumor effect of maesopsin 4-O-β-glucoside (TAT2) isolated from the leaves of Artocarpus tonkinensis (A. tonkinensis) A. Chev. ex Gagnep.
METHODS:
The antitumor activity of TAT2 was evaluated in Lewis lung carcinoma (LLC) tumor-bearing mice. BALB/c mice had tumors induced by implantation with 2 × 106 LLC cells into the subcutaneous right posterior flank. Tumor-bearing mice were treated orally with a range of doses of TAT2 and a standard drug, doxorubicin. Animals were observed for tumor growth and mortality rate. Blood was collected to determine hematological and biochemical parameters.
RESULTS:
TAT2 was isolated from an ethanolic extract of A. tonkinensis leaves. Its structure was determined by MS and NMR spectroscopy, and identified as TAT2. The compound did not show acute toxicity at the highest dose tested (2 000 mg/kg body weight). TAT2 exhibited antitumor activity by decreasing tumor growth, increasing the survival rate, and ameliorating some hematological and biochemical parameters at doses of 100 and 200 mg/kg body weight (P < 0.05).
CONCLUSIONS:
These results indicate that TAT2 possesses clear antitumor activity. Due to its bioavailability and low toxicity, and the fact that it could be isolated in a large scale from A. tonkinensis leaves, the compound shows promise as a potential anticancer drug. |
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| Publication date | 2016-03-10 |
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| Publisher | Elsevier |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| Identifier | S1995764516300128 |
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| NPARC number | 23000132 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 0cf3175c-218c-4c30-b972-d450dd66811e |
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| Record created | 2016-06-06 |
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| Record modified | 2020-06-02 |
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