National Research Council of Canada. NRC Industrial Materials Institute
Symposium W: Biological and Bioinspired Materials and Devices, April 13-16, 2004, San Francisco, CA, USA
Porous metallic scaffolds have recently gained recognition as a promising avenue toward the regeneration of damaged bone structures. Interest in these materials resides in their ability to guide bone growth by presenting a favorable structure for cellular adhesion and three-dimensional proliferation. A powder metallurgy process to fabricate titanium foams with favorable microstructural parameters for applications in bone engineering has recently been developed. This study assesses the potential of this novel material for applications as an osteoconductive scaffold through in vitro characterization of early cellular interactions with titanium foams having pore sizes ranging from 167 to 500 µm. The foams exhibit no cytotoxic effects on J774 mouse macrophages while favoring adhesion and proliferation of MC3T3-E1 pre-osteoblasts. Three-dimensional morphology assumed by these cells on porous titanium suggests that the microstructure of the foams is biomimetic.
Materials Research Society
Symposium W: Biological and Bioinspired Materials and Devices.