| DOI | Resolve DOI: https://doi.org/10.1016/0003-9861(83)90145-5 |
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| Author | Search for: Burton, G.W.1; Search for: Joyce, A.1; Search for: Ingold, K. U.1 |
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| Affiliation | - National Research Council of Canada
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| Format | Text, Article |
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| Subject | alpha tocopherol; antioxidant; blood and hemopoietic system; drug mechanism; erythrocyte membrane; human cell; human experiment; normal human; oral drug administration; plasma; adult; antioxidants; erythrocyte membrane; erythrocytes; lipids; male; membrane lipids; middle age; solubility; support, non-U. S. Gov't; vitamin E |
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| Abstract | The concentrations of lipid-soluble, chain-breaking antioxidants in human plasma and in erythrocyte ghosts have been determined for the first time by an inhibited-autoxidation method. The results are very similar to the concentrations of vitamin E measured for the same blood components by the HPLC method. It is concluded that vitamin E, which is largely present as α-tocopherol, is the only significant lipid-soluble, chain-breaking type of antioxidant present in human blood. The concentration of vitamin E-in the plasma lipids divided by the concentration of vitamin E in the ghost membrane lipids is approximately a constant despite the large differences in vitamin E-intake and in plasma lipid concentrations in different individuals. Vitamin E/lipid ratios for plasma and ghosts were larger for subjects taking a supplement of α-tocopherol acetate of 100 IU per week, compared to nonsupplemented subjects (based on data from a limited number of subjects). A larger supplement of 2800 IU per week did not significantly increase the vitamin E/lipid ratios. © 1983. |
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| Publication date | 1983 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21276660 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 0a7de89a-f1b7-40d0-bc76-b377eaecd7ed |
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| Record created | 2015-10-13 |
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| Record modified | 2020-03-13 |
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