The possible uses and challenges of nanomaterials in mast cell research

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.4049/jimmunol.1800658
AuthorSearch for: 1ORCID identifier: https://orcid.org/0000-0002-2036-9556; Search for: 1; Search for: 1ORCID identifier: https://orcid.org/0000-0003-4562-7432; Search for: ; Search for: 1ORCID identifier: https://orcid.org/0000-0003-4741-9290
Name affiliation
  1. National Research Council of Canada. Nanotechnology
FormatText, Article
Journal titleThe Journal of Immunology
ISSN0022-1767
1550-6606
Volume204
Issue8
Pages2021–2032
Abstract
Mast cells are tissue-resident immune cells that are involved in inflammation and fibrosis but also serve beneficial roles, including tissue maintenance, angiogenesis, pathogen clearance, and immunoregulation. Their multifaceted response and the ability of their mediators to target multiple organs and tissues means that mast cells play important roles in numerous conditions, including asthma, atopic dermatitis, drug sensitivities, ischemic heart disease, Alzheimer disease, arthritis, irritable bowel syndrome, infections (parasites, bacteria and viruses), and cancer. As a result, mast cells have become an important target for drug discovery and diagnostic research. Recent work has focused on applying novel nanotechnologies to explore cell biology. In this brief review, we will highlight the use of nanomaterials to modify mast cell functions and will discuss the potential of these technologies as research tools for understanding mast cell biology.
Publication date
PublisherAmerican Association of Immunologists
LanguageEnglish
Peer reviewedYes
NRC numberNRC-NANO-035
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Record identifier0765be63-eb76-4526-bd4f-cf7fc11fa478
Record created2020-06-29
Record modified2020-06-29
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