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Characterization of extremely drug-resistant and hypervirulent Acinetobacter baumannii AB030

From National Research Council Canada

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DOIResolve DOI: https://doi.org/10.3390/antibiotics9060328
AuthorSearch for: ORCID identifier: https://orcid.org/0000-0001-9396-1502; Search for: ; Search for: ; Search for: ; Search for: ORCID identifier: https://orcid.org/0000-0003-4507-4356; Search for: ORCID identifier: https://orcid.org/0000-0002-6541-1148; Search for: 1ORCID identifier: https://orcid.org/0000-0003-0958-7728; Search for: ; Search for: ; Search for: ORCID identifier: https://orcid.org/0000-0001-6395-7932
Affiliation
  1. National Research Council of Canada. Human Health Therapeutics
FormatText, Article
Subjectmultidrug resistance; virulence; gram-negative; comparative genomics; insertion elements
Abstract
Acinetobacter baumannii is an important nosocomial bacterial pathogen. Multidrug-resistant isolates of A. baumannii are reported worldwide. Some A. baumannii isolates display resistance to nearly all antibiotics, making treatment of infections very challenging. As the need for new and effective antibiotics against A. baumannii becomes increasingly urgent, there is a need to understand the mechanisms of antibiotic resistance and virulence in this organism. In this work, comparative genomics was used to understand the mechanisms of antibiotic resistance and virulence in AB030, an extremely drug-resistant and hypervirulent strain of A. baumannii that is a representative of a recently emerged lineage of A. baumannii International Clone V. In order to characterize AB030, we carried out a genomic and phenotypic comparison with LAC-4, a previously described hyper-resistant and hypervirulent isolate. AB030 contains a number of antibiotic resistance- and virulence-associated genes that are not present in LAC-4. A number of these genes are present on mobile elements. This work shows the importance of characterizing the members of new lineages of A. baumannii in order to determine the development of antibiotic resistance and virulence in this organism.
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PublisherMDPI
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  • Antibiotics 9, no. 6, 328 (17 June 2020): 1–16.
LanguageEnglish
Peer reviewedYes
Identifierantibiotics9060328
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Record identifier05d6a9da-503e-4c2d-be75-cd201feba26e
Record created2021-04-14
Record modified2021-04-19
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